- Weinberg, Robert A. 1942-
- Cancer -- Molecular aspects
- Cancer -- Genetic aspects
- Cancer cells.
- 0815340761 :
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- Includes bibliographical references and index.
- Preface Chapter 1 The Biology and Genetics of Cells and Organisms 1.1 Mendel establishes the basic rules of genetics 1.2 Mendelian genetics helps to explain Darwinian evolution 1.3 Mendelian genetics governs how both genes and chromosomes behave 1.4 Chromosomes are altered in most types of cancer cells 1.5 Mutations causing cancer occur in both the germ-line and the soma 1.6 Genotype embodied in DNA sequences creates phenotype through proteins 1.7 Gene expression patterns also control phenotype 1.8 Transcription factors control gene expression 1.9 Metazoa are formed from components conserved over vast evolutionary time periods 1.10 Gene cloning techniques revolutionized the study of normal and malignant cells Chapter 2 The Nature of Cancer 2.1 Tumors are complex tissues 2.2 Tumors arise from many specialized cell types throughout the body 2.3 Some types of tumors do not fit into the major classifications 2.4 Cancers seem to develop progressively 2.5 Tumors are monoclonal growths 2.6 Cancers occur with vastly different frequencies in different human populations 2.7 The risks of cancers often seem to be increased by assignable influences including lifestyle 2.8 Specific chemical agents can induce cancer 2.9 Both physical and chemical carcinogens act as mutagens 2.10 Mutagens may be responsible for some human cancers 2.11 Synopsis and prospects Essential Concepts Additional Reading Chapter 3 Tumor viruses 3.1 Peyton Rous discovers a chicken sarcoma virus 3.2 Rous sarcoma virus is discovered to transform infected cells in culture 3.3 The continued presence of RSV is needed to maintain transformation 3.4 Viruses containing DNA molecules are also able to induce cancer 3.5 Tumor viruses induce multiple changes in cell phenotype including acquisition of tumorigenicity 3.6 Tumor virus genomes persist in virus-transformed cells by becoming part of host cell DNA 3.7 Retroviral genomes become integrated into the chromosomes of infected cells 3.8 A version of the src gene carried by RSV is also present in uninfected cells 3.9 RSV exploits a kidnapped cellular gene to transform cells 3.10 The vertebrate genome carries a large group of proto-oncogenes 3.11 Slowly transforming retroviruses activate proto-oncogenes by inserting their genomes adjacent to these cellular genes 3.12 Some retroviruses naturally carry oncogenes 3.13 Synopsis and prospects Essential Concepts Additional Reading Chapter 4 Cellular oncogenes 4.1 Can cancers be triggered by the activation of endogenous retroviruses? 4.2 Transfection of DNA provides a strategy for detecting nonviral oncogenes 4.3 Oncogenes discovered in human tumor cell lines are related to those carried by transforming retroviruses 4.4 Proto-oncogenes can be activated by genetic changes affecting either protein expression or structure 4.5 Variations on a theme: the myc oncogene can arise via at least three additional distinct mechanisms 4.6 A diverse array of structural changes in proteins can also lead to oncogene activation 4.7 Synopsis and prospects Essential Concepts Additional Reading Chapter 5 Growth factors and their receptors 5.1 Normal metazoan cells control each other's lives 5.2 The Src protein functions as a tyrosine kinase 5.3 The EGF receptor functions as a tyrosine kinase 5.4 An altered growth factor receptor can function as an oncoprotein 5.5 A growth factor gene can become an oncogene: the case of sis 5.6. Transphosphorylation underlies the operations of receptor tyrosine kinases 5.7 Yet other types of receptors enable mammalian cells to communicate with their environment 5.8 Integrin receptors sense association between the cell and the extracellular matrix 5.9 The Ras protein, an apparent component of the downstream signaling cascade, functions as a G protein 5.10 Synopsis and Prospects Essential Concepts Additional Reading Chapter 6 Cytoplasmic Signaling Circuitry Programs Many of the Traits of Cancer 6.1 A signaling pathway reach
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