authors:- Compston, Alastair.
- McAlpine, Douglas.
subjects:publishers:- Churchill Livingstone Elsevier,
ISBN:- 044307271X (hbk)
- 9780443072710 (hbk)
notes:- Previous ed.: London: Churchill Livingstone, 1998.
- Includes index.
- Bibliography: p. 811-946.
- SECTION ONE: THE STORY OF MULTIPLE SCLEROSIS 1. The story of multiple sclerosis The evolving concept of multiple sclerosis Naming and classifying the disease: 1868-1983 Clinical descriptions of multiple sclerosis: 1838-1981 Personal accounts of multiple sclerosis: 1824-1991 The social history of multiple sclerosis: 1945-1998 The pathogenesis and clinical anatomy of multiple sclerosis: 1849-1977 The laboratory science of multiple sclerosis: 1912-1981 Discovery of glia and remyelination: 1858-1988 The aetiology of multiple sclerosis: 1883-1976 Attitudes to the treatment of multiple sclerosis: 1841-1983 SECTION TWO: THE CAUSE AND COURSE OF MULTIPLE SCLEROSIS 2. The distribution of multiple sclerosis The rationale for epidemiological studies in multiple sclerosis Definitions and statistics in epidemiology Strategies for epidemiological studies in multiple sclerosis The geography of multiple sclerosis Epidemics and clusters of multiple sclerosis The environmental factor in multiple sclerosis 3. The genetics of multiple sclerosis: Genetic analysis of multiple sclerosis Methods of genetic analysis Racial susceptibility Sex differences in susceptibility Familial multiple sclerosis Candidate genes in multiple sclerosis Systematic genome screening Lessons from genetic studies of experimental allergic encephalomyelitis Conclusions 4. The natural history of multiple sclerosis Introduction Definitions Onset Course Inter-individual variability Factors affecting the prognosis General considerations Environmental influences Chapter 5: The aetiology of multiple sclerosis: an epitome SECTION THREE: THE CLINICAL FEATURES AND DIAGNOSIS OF MULTIPLE SCLEROSIS 6. The symptoms and signs of multiple sclerosis. Multiple sclerosis as a neurological illness Initial symptoms Symptoms and signs in the course of the disease Individual symptoms and sign Associated diseases Conclusion 7. The diagnosis of multiple sclerosis Diagnostic criteria for multiple sclerosis Selection.
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